A circulating anticoagulant inhibiting antihaemophilic globulin

A Circulating Anticoagulant Inhibiting Antihaemophilic Globulin.

A circulating anticoagulant inhibiting antihaemophilic globulin (A.H.G.) is described in an otherwise healthy 70-year-old woman, and the therapeutic response to steroids is discussed. The nature and pathogenesis of the anticoagulant remain obscure, but its properties and behaviour do not support an autoimmune aetiology.

A circulating anticoagulant occurring after temporal arteritis and controlled by corticosteroid therapy.

A case is described in which a circulating anticoagulant, inhibiting antihaemophilic globulin, developed following temporal arteritis. The circulating anticoagulant disappeared with steroid therapy, reappearing when steroids were withdrawn. Permanent maintenance therapy appears necessary in this case to prevent haemorrhagic manifestations.

Electrophoretic isolation of a circulating anticoagulant.

Antihaemophilic globulin: preparation by an improved cryoprecipitation method and clinical use.

The control of bleeding episodes in haemophilia and the prevention of excessive haemorrhage after surgical procedures depend chiefly on raising the patient's plasma factor VIII concentration to an appropriate haemostatic level, and maintaining this so long as the likelihood of bleeding continues. With whole plasma it is impossible to achieve levels much above 25%, or to maintain values constant...

Aggregation of human platelets by commercial preparations of bovine and porcine antihaemophilic globulin.

Infusion of commercial preparations of porcine and bovine antihaemophilic globulin into three haemophilic patients produced transient thrombocytopenia. This platelet-aggregating activity has been shown to be present in a wide range of animal plasmas and is related to the fibrinogen fraction. The mechanism of platelet aggregation by animal fibrinogen is discussed and some inhibitors of the react...